The synthesis of substituted fluorenes as novel non-imidazole histamine h(3) inhibitors

Pauline Ting; Joe Lee; Margaret Albanese; Wing Tom; Daniel Solomon; Robert Aslanian; Neng Shih; Robert West

doi:10.1016/s0960-894x(02)00521-8

The synthesis of substituted fluorenes as novel non-imidazole histamine h(3) inhibitors

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2643-6. doi: 10.1016/s0960-894x(02)00521-8.

Authors

Pauline Ting¹, Joe Lee, Margaret Albanese, Wing Tom, Daniel Solomon, Robert Aslanian, Neng Shih, Robert West

Affiliation

¹ The Schering Plough Research Institute, 2015 Galloping Hill Road, 07033, Kenilworth, NJ, USA. pauline.ting@spcorp.com

PMID: 12182878
DOI: 10.1016/s0960-894x(02)00521-8

Abstract

A novel non-imidazole fluorene oxime 1a has been identified as a histamine H(3) inhibitor, and its structure-activity relationship has been evaluated.

MeSH terms

Fluorenes / chemical synthesis*
Fluorenes / chemistry
Fluorenes / pharmacology
Histamine H1 Antagonists / chemical synthesis*
Histamine H1 Antagonists / chemistry
Histamine H1 Antagonists / pharmacology
Receptors, Histamine H3 / drug effects*
Structure-Activity Relationship

Substances

Fluorenes
Histamine H1 Antagonists
Receptors, Histamine H3